Protein Details: β4 (Calcium-activated potassium channel subunit beta-4)
Protein ID
ICDB_Pro_1203
Protein Name
β4 (Calcium-activated potassium channel subunit beta-4)
Gene Name
KCNMB4
Organism
Homo sapiens (Human)
Length
210 amino acids
AlphaFoldDB
AF-Q86W47-F1-model_v4.pdb
Function
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1;thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel;but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations
Sequence
Ligand Binding
Binding Site
Disease
Renal Hypomagnesemia 5 With Ocular Involvement and Chondrodysplasia Punctata Syndrome
Location
Predominantly expressed in brain. In brain; it is expressed in the cerebellum; cerebral cortex; medulla; spinal cord; occipital pole; frontal lobe; temporal lobe; putamen; amygdala; caudate nucleus; corpus callosum; hippocampus; substantia nigra and thalamus. Weakly or not expressed in other tissues.
DOI ID
10.1073/pnas.100118597; 10.1016/s0014-5793(00)01584-2; 10.1074/jbc.275.9.6453; 10.1523/jneurosci.20-10-03563.2000; 10.1101/gr.2596504; 10.1074/jbc.m107682200; 10.1074/jbc.m205795200; 10.1152/nips.01387.2002; 10.1073/pnas.1423094112
RefSeq
NP_055320.4